Cardinals' offense takes another hit as John Brown won't play Week 2

Arizona Cardinals wide receiver John Brown has been ruled out of Sunday's game against the Indianapolis Colts due to a quadriceps injury, head coach Bruce Arians announced Friday.

It's a significant blow to an offense that's already preparing for a lengthy absence for star running back David Johnson.

Brown was unable to practice throughout the week after aggravating his injury in Week 1.

Jaron Brown and J.J. Nelson should take on expanded roles as the Cardinals attempt to rebound from a poor offensive performance in their 35-23 loss to the Detroit Lions.