"The decision was made out of an abundance of caution to ensure the health and safety of players, coaches, and game-day personnel, and in consultation with medical experts," read the NHL's statement.
Hurricanes general manager Don Waddell confirmed three players on Carolina's roster have tested positive for COVID-19 but added one test was a false positive, according to The Athletic's Sara Civian.
It's not currently known which players tested positive, but Hurricanes forward Jordan Staal has been on the NHL's COVID-19 protocol list for the club's past two games.
A makeup date has yet to be announced.
Carolina and Nashville played Monday night, with the Hurricanes claiming a 4-2 victory. Both the Hurricanes and Predators are scheduled for two more games this week.
This marks the NHL's first game-day postponement due to COVID-19 this season. The Dallas Stars had four games delayed before the campaign began due to an outbreak that infected several players.