Milan - Serie A title hopeful Roma was knocked out of the Coppa Italia on Wednesday as Serie B side Spezia caused a last-16 upset to advance to the quarter-finals on penalties.
After two periods of extra-time failed to produce goals, Roma midfielder Miralem Pjanic and then striker Edin Dzeko fired over the crossbar as the visitors took a 2-0 lead from the spot.
Italy midfielder Daniele De Rossi then French left-back Lucas Digne made amends by slotting their spot-kicks past Leandro Chichizola in the Spezia goal.
But it was too little too late as the second division side advanced 4-2 to set up a quarter-final tie with Lega Pro side Alessandria.
A fortnight after ending Palermo's interest in the competition with a shock 3-2 win in Sicily, Alessandria stopped Genoa's progress on Tuesday thanks to a 113th-minute winner that gave the third-division club a 2-1 win.
