It's unknown why DeAngelo's presence for Saturday's opener is in jeopardy, but he missed Friday's practice.
DeAngelo's projected partner, Marc Staal, will play despite leaving Wednesday's exhibition game, Quinn added.
DeAngelo, who played a team-high 24:09 on Wednesday, had a breakout season in 2019-20, finishing fourth among all NHL blue-liners with 53 points in 68 games.
The Rangers and Hurricanes play at 12 p.m. ET on Saturday.