Kenny Golladay will spend his fourth straight game on the sidelines after the Detroit Lions ruled the wide receiver out for Thursday's Thanksgiving Day game against the Houston Texans.
Golladay, 27, has only played in five games this season, amassing 338 receiving yards.
Lions rookie running back D'Andre Swift is listed as questionable for the contest as he continues to work his way back from a concussion. The 21-year-old missed last week's loss to the Carolina Panthers.
Swift last appeared in Week 10, making his first career start and totaling 149 yards from scrimmage.
Adrian Peterson and Kerryon Johnson will be expected to handle much of the workload if the rookie can't play.
Wide receiver Danny Amendola, cornerback Jeff Okudah, and defensive lineman Da'Shawn Hand were among the other players Detroit ruled out.
The Lions activated wide receiver Mohamed Sanu from the practice squad ahead of Thursday's contest to bolster their receiving corps.