Hopkins hasn't practiced this week but head coach Kliff Kingsbury is still "hopeful" the star wideout will be active in Week 7, according to Josh Weinfuss of ESPN.
The four-time Pro-Bowler has battled an ankle ailment for weeks but managed to appear in all six contests so far this season. He was a game-time decision against the Carolina Panthers two weeks ago.
Hopkins is off to a great start in his first season with the Cardinals. The All-Pro pass-catcher leads the NFL with 47 receptions and 601 yards through six weeks. He's also caught two touchdowns.
The game was flexed to Sunday Night Football due to the Las Vegas Raiders' COVID-19 concerns. The Raiders were initially scheduled to face the Tampa Buccaneers on the prime-time slate.
Arizona has a bye after its game with Seattle, which Kingsbury believes can help his star wideout clear the injury report.
"Hoping he can have the bye and really clear that thing up," Kingsbury said.