Brown has been battling a knee bone bruise, costing him Thursday's practice after limiting him in Wednesday's session. The knee issue could reportedly affect Brown for more than just one game.
The 23-year-old hauled in five catches for 39 yards during the Titans' 16-14 victory over the Denver Broncos in Week 1.
The 2019 second-round pick took the NFL by storm as a rookie, leading Tennessee with 52 receptions, 1,051 receiving yards, and eight touchdowns.
Additionally, Vrabel has not confirmed pass-rusher Vic Beasley (knee) and cornerback Malcolm Butler (quad) - who are listed as questionable on the team's latest injury report - for Sunday's game. Beasley was a full participant at practice in the last two days after being sidelined in Week 1.