Mahomes was asked how far he thinks he could throw a football in Mexico City during an appearance on the "Pardon My Take" podcast Monday.
"Probably 100 (yards)," Mahomes said at around the 51-minute mark. "Yeah, 'cause I got to like 80, 83 in Denver and then you have to times it by two 'cause it's like two miles above altitude. So I can handle the extra 20."
Estadio Azteca sits 7,200 feet above sea level - about 2,000 feet higher than Denver's Mile High Stadium.
The Chiefs will face the Los Angeles Chargers in Mexico City on Nov. 18.