Jones was removed after allowing three goals on seven shots.
The change briefly inspired the Sharks, as they stormed back to tie it with Aaron Dell between the pipes in a wild first period.
San Jose became the first team in playoff history to tie a game in the first period after falling behind 3-0, according to NHL Public Relations.
Jones entered the playoffs as the Sharks' biggest weakness after posting a career-worst .896 save percentage during the regular season. He was stellar in Game 1, however, allowing two goals on 26 shots in a 5-2 win.
The 29-year-old began Friday with an impressive postseason resume, owning a .926 save percentage and 2.06 goals-against average in 43 career playoff games.
Dell also struggled during the regular season, posting an .886 save percentage in 25 contests.
Cody Eakin, Colin Miller, and Max Pacioretty each notched tallies for Vegas in the opening frame, while Logan Couture, Erik Karlsson, and Joe Thornton responded for San Jose. Mark Stone scored the eventual game winner on a power play early in the second period.