MNF bets: Can Chargers hand Eagles 3rd straight loss?

The Eagles make a trip to Los Angeles to take on the Chargers for Monday Night Football. Philadelphia will look to avoid a three-game losing skid, while L.A. is in the thick of the AFC playoff race and trails the Broncos by three wins for the division lead.

Let's end the week on a winning note with our pick against the spread, favorite touchdown scorer bets, and player props to target for the Monday nighter.

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🏈 Pick: Chargers (+2.5)

Justin Herbert is expected to play despite a fracture in his left hand. However, we shouldn't be too concerned about the quarterback not making it through this game, especially after watching Aaron Rodgers handle a broken wrist in his non-throwing hand.

Although the Eagles' defense does a solid job of limiting points, they've been vulnerable on the ground, giving up 128.9 rushing yards per game (10th-most in the league). To make matters worse, Philly will be without Jalen Carter to clog up the middle of the field. Meanwhile, the Chargers are welcoming back Omarion Hampton, giving them a nice one-two punch with Kimani Vidal. The boost in the backfield should help Los Angeles control the clock and keep Herbert out of harm's way.

This pick is more of a play against the Eagles than one for the Chargers. Philadelphia has looked disjointed for a month, failing to score more than 21 points in four November outings. The Chargers also boast a strong defense that's holding opponents to the second-fewest yards (292.2) and 11th-fewest points (21) per game. Monday's contest likely won't turn into a shootout, with the game total at 41.5 points, which makes backing the home underdog a smart side to take.

NFL news editor Brenden Deeg is our "Anytime TD Guy," providing touchdown scorer props all season long.

🙌 Bet: Anytime TD (+185)

The rookie rusher returns Monday night after missing significant time with an ankle injury. Hampton was a workhorse for Los Angeles before the issue, playing over 77% of the offensive snaps in his last four contests. Chicago ran all over Philadelphia's defense last week, opening the door for Hampton to have a big night in his first game back.

🙌 Bet: Anytime TD (+300)

Passing on these odds is tough since Goedert has seven touchdowns in 11 games this season. The 30-year-old leads the Eagles in red-zone receptions in 2025 and will face a Chargers defense that's allowed the sixth-most scores to opposing tight ends.

🏈 Bet: Over 11.5 rushing attempts

While Hampton is expected to split time with Vidal, he should still see a bunch of work in his return. Given the Eagles' struggles against the run and Herbert nursing a broken hand, the Chargers' game plan should be straightforward: rush the ball frequently. Even if Vidal handles 10 carries, Hampton should still hit this over, something he's done in four of five games this year.

🏈 Bet: Over 1.5 receptions

Rookie Tre Harris has secured two-plus receptions in six of his last seven contests, catching 88.9% of his targets over that stretch. You can get this prop at plus-money, which seems like incredible value considering his hit rate.

🏈 Bet: Under 7.5 rushing attempts

Hurts has become a selective runner amid his team's struggles, rushing eight or more times just once since the start of October. With the Eagles holding some wiggle room in the NFC East, there's little reason for him to put his body at risk in an inter-conference matchup against the Chargers. Expect a few tush pushes, but Hurts shouldn't call his own number more than seven times.

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