The New Orleans Saints ruled out running back Alvin Kamara for Sunday's game against the Tennessee Titans due to a knee injury, according to ESPN's Adam Schefter.
The four-time Pro Bowler didn't practice all week.
Head coach Sean Payton described Kamara's ailment as "a knee injury that he's rehabbing (to return) as quickly as he can get back," according to ESPN's Mike Triplett.
Payton noted that the star rusher dealt with soreness toward the late stages of last week's game against the Atlanta Falcons.
Kamara leads the team with 530 rushing yards, seven total touchdowns, and 32 receptions.
Mark Ingram is expected to receive the majority of carries in Kamara's absence. The three-time Pro Bowler has rushed for 70 yards on 15 attempts since rejoining the Saints via a trade from the Houston Texans.
Ty Montgomery and Dwayne Washington are also expected to see some time in the backfield.
Ingram needs just 22 rushing yards on Sunday to surpass Saints legend Deuce McAllister as the franchise's all-time leader.
The Saints also ruled out left tackle Terron Armstead and defensive back C.J. Gardner-Johnson. Armstead previously missed two games due to an elbow issue, while Gardner-Johnson is wearing a walking boot on his right foot.
The Saints will attempt to end the Titans' five-game winning streak.
