Eagles' Sanders considered week-to-week with ankle injury
"It's a stretch for him to be up this week, but we're not ruling anything out yet," Sirianni added.
The third-year tailback exited the contest after linebacker Denzel Perryman tackled him in the second quarter, and he did not return.
Sanders, 24, rushed 30 yards on six carries before leaving the game. The Eagles split carries between rookie Kenneth Gainwell and Boston Scott, who combined for 44 rushing yards. Quarterback Jalen Hurts led the way with 61 yards on the ground.
The injury to Philadelphia's feature back comes while the team is emphasizing its commitment to the run game after Sanders had just nine rushing attempts in Week 6's 28-22 loss to the Tampa Bay Buccaneers.
The Penn State alum's status will remain up in the air ahead of Sunday's clash against the winless Detroit Lions, who allows 120 rushing yards per game.