Super Bowl odds update: Bills favored to win it all after walloping Chiefs

We saw one of the biggest shifts in the Super Bowl market this week, as the Bills took over as the co-favorites and the Seahawks fell out of the title picture. Those weren't the only teams whose fates changed since a week ago.

Here are the current Super Bowl odds at theScoreBet and three of the biggest risers and fallers after Week 5:

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Buffalo Bills (+550)

Say hello to your new Super Bowl front-runners. The Bills ripped the belt from the Chiefs after pummeling them 38-20 in prime time at Arrowhead Stadium, marking Patrick Mahomes' first home loss over his last eight starts.

Through five weeks, Buffalo ranks first in scoring offense (34.4 points per game), scoring defense (12.8), and has a scoring differential (+108) nearly double that of the next-best team. The Bills also have the easiest remaining schedule of any team in the NFL, so these odds may only get shorter ahead of the postseason.

Arizona Cardinals (+1200)

The NFL's lone undefeated team kept rolling on Sunday - this time with its defense. The Cardinals held the 49ers scoreless in the first half of Sunday's 17-10 win but engineered a late scoring drive to stay perfect and maintain a one-game lead over the Rams in the NFC West.

It was an uncharacteristic display for MVP favorite Kyler Murray, who scored just one touchdown and finished with one rushing yard. It didn't matter, and it showed just how dangerous this team can be down the stretch even when Murray isn't winning it by himself.

Los Angeles Chargers (+1600)

The Justin Herbert hype has reached DEFCON levels, but it's hard not to get excited with how well the Chargers quarterback is playing in just his second season. On Sunday, the former top-six pick threw for 398 yards and four touchdowns and added another score on the ground in a wild 47-42 win over the Browns.

The win catapulted Los Angeles from 22-1 to 16-1, which is the clear mark of delineation in the current Super Bowl market. The Chargers' offense is legit, and the defense is better than it showed last week. Watch out for the Bolts as dark horse title contenders and potential AFC West champions, too.

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San Francisco 49ers (+3300)

After seeing his first bit of game action last week, rookie quarterback Trey Lance was thrown into the fire in his first career start on Sunday. It didn't exactly meet expectations, further hindering his team's already murky title prospects.

The No. 3 pick threw for 192 yards and added 89 on the ground but finished with zero touchdowns in Sunday's loss to the Cardinals. He also completed just 15 of his 29 attempts and airmailed an interception to safety Budda Baker, one of many errant throws through Lance's first seven quarters. If he can't clean up his game soon, it may be too late for the Niners to turn things around.

Seattle Seahawks (+7000)

When one of the best quarterbacks in football goes down for an extended period, it's sure to crush that team's Super Bowl outlook. That's the case for the Seahawks, who tumbled from 28-1 to 70-1 after Russell Wilson underwent surgery for a finger injury sustained in Thursday's loss.

His recovery is expected to sideline him for six-to-eight weeks, though there's some optimism he could return after just four weeks. Even if he does, Seattle can't afford to fall back any further in the cutthroat NFC West after a 2-3 start, which puts this group three games back of the division lead.

Las Vegas Raiders (+7000)

The Raiders' stint as the AFC's lone undefeated team was short-lived, and it hasn't been pretty since. Las Vegas' offense sputtered in Sunday's 20-9 loss to the Bears, marking the second straight week this team was held to two scores or less after it averaged 30 points through its first three games.

The bigger concern is with this defense, which allowed Chicago to rush for 143 yards just six days after surrendering 168 rushing yards to the Chargers. Upcoming games against the run-heavy Broncos and Eagles means things could get worse before they get better.

C Jackson Cowart is a sports betting writer at theScore. You can follow him on Twitter (@CJacksonCowart) or email him at cjackson.cowart@thescore.com.