Star runner Alvin Kamara tested positive for COVID-19 this week.
The Saints' running game will now rely on the legs of running back/wide receiver Ty Montgomery. He's recorded just a single carry this season.
Quarterback Taysom Hill could see an increased role Sunday. Hill has rushed for 416 yards and seven touchdowns entering the final week of the regular season.
New Orleans needs a win against the Panthers in Week 17 to have a chance at claiming the NFC's top playoff seed.