Jones has been bothered by a hamstring injury, while Gurley is dealing with a knee issue. Both players practiced in a limited capacity Friday after missing the Falcons' previous game against the Las Vegas Raiders.
Jones, 31, has looked dominant when healthy this season, but injuries have sidelined him for three games. The seven-time Pro Bowler has totaled 677 receiving yards in 2020, and his 77.6 catch percentage would stand as a career high.
Gurley has been Atlanta's lead rusher this season, accumulating 610 yards on the ground and nine touchdowns. But the 26-year-old has struggled with consistency, averaging under three yards per carry in five contests this year.
The Falcons started the season 0-5 but have caught fire recently, winning four of their last six contests. Atlanta is looking to close the campaign on a strong note under interim head coach Raheem Morris.