Pederson informed his players Sunday after a second positive test confirmed his diagnosis, according to ESPN's Tim McManus.
The 52-year-old is asymptomatic and feeling fine. He's believed to have contracted the coronavirus outside of the team's training facility.
Philadelphia also reportedly sent home a staff member who was in close contact with Pederson.
Pederson is the second known NFL head coach to test positive. Sean Payton of the New Orleans Saints contracted the coronavirus in March and has since recovered.
The Eagles have gone 38-26 in Pederson's four seasons at the helm, winning Super Bowl LII in 2017.