Fuller was officially listed as questionable heading into Thursday. He's missed the Texans' past three contests since suffering a hamstring injury in the first meeting between the division rivals in Week 7.
The 25-year-old wideout has now missed 20 games throughout his career due to injury and has yet to play a full campaign.
Despite being sidelined, Fuller has the second-most catches (34) and receiving yards (450) for Houston this season, behind DeAndre Hopkins.
The Texans went 2-1 without Fuller. They enter Thursday night's matchup with a 6-4 record.