The fine money will be donated to Mothers Against Drunk Driving.
The Cardinals executive will be barred from team facilities during his suspension, which begins immediately. He'll be unable to return until he has completed counseling and a DUI education course.
Keim won't be subject to additional discipline from the NFL if he fulfills the Cardinals' requirements, a league spokesperson told AZCentral's Kent Somers.
"Once again, I apologize to everyone who has been negatively impacted by my actions and incredibly poor judgment - in particular, the Cardinals, our fans, and my family," Keim said in a statement. "I fully deserve and accept the punishment that has been issued. My goal is to do everything I can to grow from this personally and help others learn from my inexcusable behavior."
In Keim's absence, GM duties will be divided among members of Arizona's personnel department.
"As stated at the time of the incident, this behavior is indefensible and completely unacceptable," the Cardinals said in a statement. "While Steve has accepted full accountability and responsibility for his actions, that does not diminish their gravity nor the severity of the consequences that result from them."
Keim was arrested and cited for DUI on July 4. According to the Chandler Police Department, his blood alcohol content was .19. In Arizona, extreme DUI charges are filed when blood alcohol content is above .15. The legal limit for a standard DUI is .08.
The Cardinals recently signed the general manager to an extension through the 2022 season. He'll return to his position before the team finalizes its 53-man roster.