American Sofia Kenin has lost in the fourth round at the French Open to Maria Sakkari of Greece, 6-1, 6-3.
At No. 4, Kenin was the highest-seeded player left in the tournament. She was the runner-up at Roland Garros last October, and was seeking her second major title.
Sakkari, seeded 17th, advanced to her first career Grand Slam quarterfinal and earned her sixth win against a top-20 player this year.
Kenin lost serve six times and had 32 unforced errors to 15 for the steady Sakkari.