The international break always seems to bring a slew of untimely injuries, but with matches taking place - somehow - during a pandemic, the now-complete November window came with increased risk and repercussions. Below, we review the marquee players and teams impacted, either by COVID-19 or an injury, ahead of club football's return this weekend.
Mohamed Elneny (Arsenal): Tested positive twice, most recently on Wednesday, while with Egypt. His status for Sunday's match against Leeds United is unclear.
Conor Coady (Wolverhampton Wanderers): Withdrew from the England squad and entered self-isolation after coming into contact with somebody who tested positive. The defender has twice tested negative for COVID-19 since.
Lucas Torreira (Atletico Madrid): Tested positive after returning from international duty with Uruguay.
Sergej Milinkovic-Savic (Lazio): Tested positive after a mini-outbreak hit the Serbia squad; Inter Milan's Aleksandar Kolarov and Luka Milivojevic of Crystal Palace were also among five Serbian players to contract the disease.
Marcelo Brozovic (Inter Milan): Tested positive while with Croatia. Compatriot Domagoj Vida was informed that he tested positive after playing in a friendly with Turkey, and Brozovic's result came in two days later.
Diego Rossi (LAFC): Major League Soccer's regular-season Golden Boot winner returned a positive test while with Uruguay and will likely miss his team's playoff opener on Nov. 24.
It's possible that any of the players above could test negative for the novel coronavirus and be cleared in time to feature for their clubs this weekend, though the travel element that comes with an international window and subsequent quarantine procedures complicate the matter.
Previous international breaks in recent months saw the likes of Cristiano Ronaldo, Kylian Mbappe, and Paul Pogba contract COVID-19.
Joe Gomez (Liverpool): Underwent surgery after damaging a tendon in his left knee during an England training session. The defender is expected to miss a "significant part" of the rest of the season.
Jordan Henderson (Liverpool): Left England's Nations League match against Belgium at halftime after experiencing leg tightness. The severity of the issue, and his status for the weekend, is unclear.
Harry Maguire (Manchester United): Played 90 minutes in England's recent win over Iceland, but reportedly complained of bruising to his foot in the aftermath. His condition will be assessed by Manchester United.
Raheem Sterling (Manchester City): Missed England's contest with Belgium due to an undisclosed ailment. It's believed the winger tweaked a calf muscle during a training session.
Sergio Busquets (Barcelona): Was ruled out of the aforementioned win over Germany after suffering a left knee sprain in the team's previous Nations League match against Switzerland. As a result, he won't play this weekend versus Atletico Madrid.
Rafael Leao (AC Milan): Expected to miss two weeks after suffering a thigh injury while playing for Portugal's Under-21 side.
Various players and coaches have been outspoken about their displeasure with the congested fixture list, an issue that has only been heightened by the coronavirus pandemic. Crammed schedules, international travel, and, in the Premier League's case, a refusal to adopt the five-substitutes rule have conspired to cause more fatigue - and, in turn, injuries - than ever.
Frank Lampard (Chelsea): "My main concern is player welfare. They are under incredible stress, especially those playing in Europe. I don't want anyone to cry their eyes out for players, we all know how lucky we are, but everywhere else has five subs, so we have to revisit this, in my opinion."
Pep Guardiola (Manchester City): "LeBron James won the NBA title and now he is on holiday for one or two months. Our guys had eight days. It's games, games, games, because TV decided to do it."