Trevor Moore will need some additional time to recover.
Moore will miss at least the next two games due to the NHL's mandatory minimum of seven days spent on IR, retroactive to the day of the injury.
The 24-year-old suffered the shoulder ailment in a loss to the Boston Bruins on Friday and missed Saturday's defeat at the hands of the Pittsburgh Penguins.
Moore has produced three goals and five points while averaging exactly 14 minutes of ice time across 21 contests this season.
Toronto's six-game road trip will continue with a matchup against the Vegas Golden Knights on Tuesday, a meeting with the Arizona Coyotes on Thursday, and a battle with the Colorado Avalanche on Saturday.