Bills head coach Rex Ryan said after the game that running back LeSean McCoy is playing on "one and a half legs."
McCoy, who's been dealing with a hamstring injury, rushed for a paltry 16 yards on 11 carries, and was seen riding an exercise bike in the second half. The 2013 rushing leader did, however, catch a 10-yard touchdown pass.
Ryan was asked whether he would give McCoy a week off, and answered that the team would need him even if he's only at 80 percent, according to ESPN's Mike Rodak.
It was confirmed that McCoy is still working his way back to full health.
McCoy doesn't know if he'll be able to play in the Bills' Week 4 game against the New York Giants.
"We're going to find out. I'm not sure," McCoy told Tyler Dunne of The Buffalo News.
Karlos Williams starred as the Bills' feature back Sunday, rushing for 110 yards and a touchdown on 12 carries. If McCoy's hamstring continues to be an issue, the Bills' rookie could ascend to starter status.