The NFL announced its complete 2021 regular-season schedule Wednesday. See below for matchups, dates, and start times for the Los Angeles Rams.
| Week | Opponent | Date | Time (ET) |
|---|---|---|---|
| 1 | vs. Bears | Sept. 12 (SNF) | 8:20 p.m. |
| 2 | at Colts | Sept. 19 | 1 p.m. |
| 3 | vs. Buccaneers | Sept. 26 | 4:25 p.m |
| 4 | vs. Cardinals | Oct. 3 | 4:05 p.m. |
| 5 | at Seahawks | Oct. 7 (TNF) | 8:20 p.m. |
| 6 | at Giants | Oct. 17 | 1 p.m. |
| 7 | vs. Lions | Oct. 24 | 4:05 p.m. |
| 8 | at Texans | Oct. 31 | 1 p.m. |
| 9 | vs. Titans | Nov. 7 (SNF) | 8:20 p.m. |
| 10 | at 49ers | Nov. 15 (MNF) | 8:15 p.m. |
| 11 | Bye | - | - |
| 12 | at Packers | Nov. 28 | 4:25 p.m. |
| 13 | vs. Jaguars | Dec. 5 | 4:25 p.m. |
| 14 | at Cardinals | Dec. 13 (MNF) | 8:15 p.m. |
| 15 | vs. Seahawks | Dec. 19 | 4:25 p.m. |
| 16 | at Vikings | Dec. 26 | 1 p.m. |
| 17 | at Ravens | Jan. 2 | 4:25 p.m. |
| 18 | vs. 49ers | Jan. 9 | 4:25 p.m. |
