The NFL announced its complete 2021 regular-season schedule Wednesday. See below for matchups, dates, and start times for the Detroit Lions.
| Week | Opponent | Date | Time (ET) |
|---|---|---|---|
| 1 | vs. 49ers | Sept. 12 | 1 p.m. |
| 2 | at Packers | Sept. 20 (MNF) | 8:15 p.m. |
| 3 | vs. Ravens | Sept. 26 | 1 p.m. |
| 4 | at Bears | Oct. 3 | 1 p.m. |
| 5 | at Vikings | Oct. 10 | 1 p.m. |
| 6 | vs. Bengals | Oct. 17 | 1 p.m. |
| 7 | at Rams | Oct. 24 | 4:05 p.m. |
| 8 | vs. Eagles | Oct. 31 | 1 p.m. |
| 9 | Bye | - | - |
| 10 | at Steelers | Nov. 14 | 1 p.m. |
| 11 | at Browns | Nov.21 | 1 p.m. |
| 12 | vs. Bears | Nov. 25 (Thanksgiving) | 12:30 p.m. |
| 13 | vs. Vikings | Dec. 5 | 1 p.m. |
| 14 | at Broncos | Dec. 12 | 4:05 p.m. |
| 15 | vs. Cardinals | Dec. 19 | 1 p.m. |
| 16 | at Falcons | Dec. 26 | 1 p.m. |
| 17 | at Seahawks | Jan. 2 | 4:25 p.m. |
| 18 | vs. Packers | Jan. 9 | 1 p.m. |
