The NFL announced its complete 2021 regular-season schedule Wednesday. See below for matchups, dates, and start times for the Indianapolis Colts.
| Week | Opponent | Date | Time (ET) |
|---|---|---|---|
| 1 | vs. Seahawks | Sept. 12 | 1 p.m. |
| 2 | vs. Rams | Sept. 19 | 1 p.m. |
| 3 | at Titans | Sept. 26 | 1 p.m. |
| 4 | at Dolphins | Oct. 3 | 1 p.m. |
| 5 | at Ravens | Oct. 11 (MNF) | 8:15 p.m. |
| 6 | vs. Texans | Oct. 17 | 1 p.m. |
| 7 | at 49ers | Oct. 24 (SNF) | 8:20 p.m. |
| 8 | vs. Titans | Oct. 31 | 1 p.m. |
| 9 | vs. Jets | Nov. 4 (TNF) | 8:20 p.m. |
| 10 | vs. Jaguars | Nov. 14 | 1 p.m. |
| 11 | at Bills | Nov. 21 | 1 p.m. |
| 12 | vs. Buccaneers | Nov. 28 | 1 p.m. |
| 13 | at Texans | Dec. 5 | 1 p.m. |
| 14 | Bye | - | - |
| 15 | vs. Patriots | Dec. 18/19 | TBD |
| 16 | at Cardinals | Dec. 25 (Sat.) | 8:15 p.m. |
| 17 | vs. Raiders | Jan. 2 | 1 p.m. |
| 18 | at Jaguars | Jan. 9 | 1 p.m. |
