The NFL announced its complete 2021 regular-season schedule Wednesday. See below for matchups, dates, and start times for the Tampa Bay Buccaneers.
| Week | Opponent | Date | Time (ET) |
|---|---|---|---|
| 1 | vs. Cowboys | Sept. 9 (Thurs.) | 8:20 p.m. |
| 2 | vs. Falcons | Sept. 19 | 4:05 p.m. |
| 3 | at Rams | Sept. 26 | 4:25 p.m. |
| 4 | at Patriots | Oct. 3 (SNF) | 8:20 p.m. |
| 5 | vs. Dolphins | Oct. 10 | 1 p.m. |
| 6 | at Eagles | Oct. 14 (TNF) | 8:20 p.m. |
| 7 | vs. Bears | Oct. 24 | 4:25 p.m. |
| 8 | at Saints | Oct. 31 | 4:25 p.m. |
| 9 | Bye | - | - |
| 10 | at Washington | Nov. 14 | 1 p.m. |
| 11 | vs. Giants | Nov. 22 (MNF) | 8:15 p.m. |
| 12 | at Colts | Nov. 28 | 1 p.m. |
| 13 | at Falcons | Dec. 5 | 1 p.m. |
| 14 | vs. Bills | Dec. 12 | 4:25 p.m. |
| 15 | vs. Saints | Dec. 19 (SNF) | 8:20 p.m. |
| 16 | at Panthers | Dec. 26 | 1 p.m. |
| 17 | at Jets | Jan. 2 | 1 p.m. |
| 18 | vs. Panthers | Jan. 9 | 1 p.m. |
