Jeffery suffered the non-contact injury at the beginning of a route early in the second quarter. He's scheduled to undergo an MRI on Tuesday.
It's not believed to be an Achilles injury, Garafolo added.
Eagles right tackle Lane Johnson also left Monday's game with an injury, which is believed to be a high ankle sprain, a source told John Clark of NBCSPhilly. Johnson was injured when Philadelphia quarterback Carson Wentz and a New York Giants defender fell into his leg.
An X-ray revealed no broken bones. Johnson will also undergo an MRI on Tuesday to determine the severity of his injury.