Mosley has missed the Jets' last four games after suffering a groin injury in the season opener.
New York's defense has held up without Mosley, ranking 19th in yards allowed per game. However, the prized offseason free-agent acquisition is still an important piece to the team's success.
"As impactful as getting a starting quarterback back," head coach Adam Gase said on Wednesday of Mosley's return, according to SNY's Ralph Vacchiano. "It's that impactful."
New York made Mosely, a four-time Pro Bowler with the Baltimore Ravens, the NFL's highest-paid inside linebacker at $18 million per season in March. Bobby Wagner's extension in July exceeded his deal.