The 30-year-old left Sunday's game against the New York Jets after just two carries for one yard.
McCoy is averaging a career-worst 3.3 yards per attempt this season for 479 rushing yards on 145 carries to go along with just two touchdowns. He's added 210 yards on 29 receptions, without a score through the air.
Rookie quarterback Josh Allen finished as the team's leading rusher in Sunday's 27-23 loss. He gained 101 yards and scored a touchdown on nine carries. It was Allen's second consecutive game topping 100 yards on the ground and his fifth rushing score of the season.