Brown (undisclosed) is questionable for Friday's game against Florida State.
Analysis:Brown's potential absence would be huge for Louisville, as the star tailback has been a key player for the Cardinals early in the 2026 campaign. In five games, he has 38 carries for 367 yards and three scores, plus two catches for 18 yards on three targets. If Brown ends up missing this game, look for Marquise Davis and Lekhy Thompkins to play a complementary role to Isaac Brown in the backfield.