Ingram's listed as questionable on the team's official injury report.
Ingram ranks fourth in the league with 922 rushing yards, with another 255 coming as a receiver. He has nine rushing touchdowns, already matching a career best set in 2014.
His absence would leave rookie Alvin Kamara with a full workload this week. Kamara has a total of 1,220 yards from scrimmage and 11 touchdowns while emerging as a favorite for the Offensive Rookie of the Year award.
This week's key divisional matchup comes with the Saints holding a record of 9-3, two wins better than the 7-5 Falcons. The two teams will meet again in Week 16 in New Orleans.
Saints rookie cornerback Marshon Lattimore is also listed as questionable with an ankle injury.