Michigan has also paused all team activities until at least Dec. 7.
"We have seen an increase in the number of student-athletes unavailable to compete due to positive COVID-19 tests and associated contact tracing due to our most recent antigen and PCR testing results," said athletic director Warde Manuel.
The Wolverines' coronavirus issues could also potentially jeopardize next weekend's matchup with Ohio State as well as the Buckeyes' eligibility for the Big Ten title game.
OSU has played four games so far this season - all wins - and needs to meet the six-game minimum threshold to play in the championship contest. Michigan is its final scheduled game.
The program's matchup against Illinois was canceled last week following positive COVID-19 test results among players and staff, including head coach Ryan Day. OSU is still currently scheduled for Saturday's game against Michigan State.
The Buckeyes currently sit in the fourth and final playoff spot of the College Football Playoff rankings and a Big Ten title would likely go a long way towards ensuring they qualify for the semifinals.