Just before halftime, with the Tigers leading 42-7, Bryant took a shot to the leg following a throw. Missouri head coach Barry Odom declared him out for the remainder of the contest shortly after the hit.
The senior quarterback was seen exiting the locker room using crutches.
Bryant began 2018 with Clemson, splitting time with freshman Trevor Lawrence before the latter was named the team's starter. Lawrence would go on to lead Clemson to a national title, and Bryant transferred for the opportunity to start.
Bryant has led Missouri to a 3-1 start. He entered Saturday's game with 1,025 passing yards, eight touchdowns, and three interceptions. The pivot then added 221 passing yards and three touchdowns against Troy.