The Lakers confirmed an earlier report that James will not accompany the team on its upcoming two-game road trip.
The 14-time All-Star has participated in on-court activities - including shooting - but has not taken part in a full practice session since suffering a groin injury Christmas Day against the Golden State Warriors.
The news all but ensures James will set a new career record for most missed contests in a regular season; the most he'd previously sat out was 13. As of Wednesday, he had missed 11 straight.
The Lakers are 4-7 without him.