The penultimate round of the FA Cup will feature a pair of heavyweight bouts, with some of the Premier League's top clubs battling for a chance to win the 139th edition of the competition.
The four remaining clubs have won the competition 39 times between them, with Arsenal holding the all-time record with 13 FA Cup trophies. United have won 12 times.
City secured their sixth FA Cup by thrashing Watford 6-0 last year.
The semifinal encounters are scheduled to take place July 18 and 19.