Bills' Enemkpali suffers 'major' knee injury vs. Colts

Buffalo Bills linebacker IK Enemkpali was carted from the field Saturday during the club's preseason opener against the Indianapolis Colts with an apparent injury.

Head coach Rex Ryan said Enemkpali suffered what looks like a "major" knee injury, according to ESPN's Mike Rodak.

Enemkpali appeared to twist his right leg awkwardly while rushing the passer. He was attended to by trainers before the cart was brought onto the field to take him for further evaluation.

With injuries to rookie Shaq Lawson and Manny Lawson, Enemkpali is currently set to start Week 1. If he, too, was sidelined, it would further expose the Bills' lack of depth at outside linebacker.

Enemkpali is arguably best known for breaking Geno Smith's jaw when both players were with the New York Jets.