Report: LeSean McCoy to miss game vs. Dolphins, possibly more time

Buffalo Bills running back LeSean McCoy will miss this Sunday's game against the Miami Dolphins with a hamstring injury and could be out longer depending on how the injury heals, sources told ESPN's Josina Anderson.

While the injury appears to be significant, McCoy is still considered a game-time decision, a source with direct knowledge of the situation told John wawrow of The Associated Press.

McCoy couldn't finish practice Wednesday after suffering the injury. The 28-year-old has yet to miss a game this year after dealing with injuries all throughout last season. He's rushed for 587 yards, the second-highest total in the league this year, and has seven touchdowns through six games.

Fantasy Fallout: LeSean McCoy's absence should let Mike Gillislee run wild

In McCoy's absence, Mike Gillislee will likely take over most of the carries with Reggie Bush helping in passing situations and rookie Jonathan Williams getting some rotational work.