Three of Meyer's seven victories came by at least two touchdowns, but the former Buckeyes boss showed little remorse for the repeated blowouts.
"This is going to create a lot of headlines, but no," Meyer told "The Dan Patrick Show" on Tuesday when asked if he'd ever felt sorry for running up the score against the Wolverines.
"Our players work that game every year," he added. "If you get a chance and go in and play (versus Michigan), I'm not going to tell them to slow down."
Ohio State hasn't lost to Michigan since 2011 and owns a 17-3 record in The Game this century. Meyer retired in 2019, and Ryan Day led the Buckeyes to a 56-27 victory last season.
This year's matchup between the bitter Big Ten rivals is set for Dec. 12 in Columbus.