Urias pulled his left hamstring in the eighth inning of a 2-1 victory over the Seattle Mariners on Tuesday and is doubtful for the remainder of the season.
"I don't think it looks particularly good, given the amount of time we have left in the season," Padres manager Andy Green said, according to MLB.com's AJ Cassavell. "We'll see how he responds to treatment. Hopefully it's nothing big, but he's doubtful at this point in time."
Before debuting in the big leagues on Aug. 28, Urias was ranked as the 22nd-best prospect in baseball - No. 4 in the Padres' system - by MLB Pipeline. He was also considered the top second-base prospect in the game.
In 48 at-bats with San Diego, the 21-year-old native of Mexico slashed just .208/.264/.354 along with two home runs and five RBIs.
Despite his below-average numbers at the plate, San Diego was pleased with what they saw from the youngster during his limited action.
"There's a lot to like," Green explained. "He's really defended the field. He's looked so good at second base, made a diving play almost every time he's had a chance to. They've been big plays. And he's turned double plays well.
"At the plate, I don't think he really found his rhythm or his stride, but you don't read too terribly much into that. He had some good swings at times. The numbers aren't going to be what he'd want them to be for his first short stint in the big leagues. But I don't think anybody's too concerned. He's got a long track record."