Manchester United creative spark Juan Mata had a golden opportunity to bring the hosts level with Midtjylland until his weak effort drew the ire of supporters at Old Trafford.
After Ander Herrera was fouled in the area, Mata was tasked with taking the penalty and ultimately blew it when his strike was easily collected by Mikkel Andersen to maintain a 3-2 aggregate scoreline in favour of the Danish side.