The San Francisco 49ers selected Louisville running back Isaac Guerendo in the fourth round of the 2024 NFL Draft, 129th overall.

Guerendo adds a ton of athleticism to the 49ers' backfield. He tore up the NFL combine with excellent testing and should help spell superstar Christian McCaffrey as a rookie.

Pre-draft profile

Guerendo is a special athlete. He made some money for himself at the combine, posting the sixth-ranked Relative Athletic Score among all running backs since 1987. His rare combination of size, speed, and fluidity also shows up on tape. That Guerendo only got 99 carries across four years at Wisconsin could be interpreted as a negative, but he was stuck in some pretty talented running back rooms. We started to see glimpses of his potential this past season after he transferred to Louisville, and he now makes the jump to the NFL with plenty of tread left on his tires. He'll have to improve his processing between the tackles, but a gap-heavy scheme could alleviate some of those issues and help him shine early on. Keep an eye on Guerendo as a sleeper in this class.