The team did not release further details on the procedure or the expected time frame for Pouncey's return, but Ed Bouchette of the Pittsburgh Post-Gazette later reported that the veteran lineman sustained a broken fibula above his left ankle.
Pouncey was named as a first-team All-Pro for the second time in his career last season. The 26-year-old is considered the anchor of a talented offensive line that is among the elite run-blocking units in the NFL.
During Sunday's contest, Pouncey was carted off the field after Packers safety Ha Ha Clinton-Dix crashed into his leg during a run play.
If Pouncey is out for a prolonged period, expect Cody Wallace to replace him in the starting lineup.