The NFL's No. 1 defense allowed 484 total yards and 32 points against.
Donald, the league's premier defensive tackle, only played in 39 of 72 defensive snaps as he battled through a torn rib cartilage suffered last week. The 29-year-old saw just 12 snaps in the second half, and the Packers responded by gashing the Rams on the ground.
"I love Aaron Donald, it means a lot to him. It's unfortunate that he wasn't at full strength today," Rams head coach Sean McVay said after the loss.
The three-time Defensive Player of the Year was seen in tears on the sideline as the game came to a close.
"He wants to be able to really make a big difference week in and week out, and I think in some instances, he felt like with the way that he feels like he can contribute, that's where I think he was upset," McVay said. "But, I love him and, you know, very thankful to work with players like him."