NFL Game Summary - Buffalo at New Orleans

New Orleans, LA (SportsNetwork.com) - Drew Brees threw five touchdown passes and hit 10 different targets, as the New Orleans Saints shook off the rust to post a 35-17 victory over the Buffalo Bills at the Superdome.

Brees had 332 yards on 26-of-34 passing for the Saints (6-1), who were coming off their bye. They suffered their lone loss of the season in heartbreaking fashion a week earlier at New England on a last-second touchdown pass by Tom Brady.

Star tight end Jimmy Graham and rookie wide receiver Kenny Stills both had two touchdown receptions for New Orleans. Graham was questionable heading into Sunday after suffering a foot injury against the Patriots, who held him without a catch.

Buffalo quarterback Thad Lewis was under pressure from the get-go. He fumbled three times, losing two, and threw an interception while completing 22-of-39 passes for 234 yards with one touchdown pass to wideout Stevie Johnson.

Johnson and tight end Scott Chandler both had 72 yards on seven catches for Buffalo (3-5), which has lost three of its last four games.