"This is certainly a difficult day for me and for my family," Miles said in a statement. "I love this university and the young men in our football program. I have truly enjoyed being the head coach at KU and know that it is in a better place now than when I arrived.
"To our student-athletes, I want you to remember that you came to play for KU and earn a degree here. So, I implore you to stay and build on what we started and do all of the things we talked about doing together. There is a bright future for all of you and for KU Football."
Miles was placed on administrative leave Friday. An investigation into how LSU handled past sexual misconduct complaints revealed athletic director Joe Alleva recommended Miles be fired with cause in 2013.
While at LSU, Miles had been accused of "texting female students, taking them to his condo alone, making them feel uncomfortable, and, on at least one occasion, kissing a student and suggesting they go to a hotel after telling her he could help her career."
The Jayhawks hired Miles in 2019, hoping the former national champion could revitalize one of the most desperate football programs in the FBS. He went 3-9 in his inaugural season, and 0-9 in his second campaign.
"I am extremely disappointed for our university, fans, and everyone involved with our football program," athletic director Jeff Long stated. "There is a lot of young talent on this football team, and I have no doubt we will identify the right individual to lead this program.
"We will begin the search for a new head coach immediately with an outside firm to assist in this process. We need to win football games, and that is exactly what we're going to do."
Kansas will release the terms of the separation in the coming days. Mike DeBord, who was named the acting head coach when Miles was put on leave, will continue to serve as head coach on an interim basis.