Skalski was given the penalty following a massive hit on Buckeyes quarterback Justin Fields. He led with the crown of his helmet into Fields' midsection, a clear violation of the rule.
Fields left the game but returned one play later to throw a touchdown pass, extending Ohio State's lead to 28-14. However, his return may be short-lived, as Fields quickly headed for the injury tent after that play.
It's the second straight game in the Superdome in which Skalski has been ejected for targeting. He was also disqualified during last year's national championship versus LSU.