The four-time All-Star mustered just nine points on 2-of-12 shooting as he saw his franchise-record double-figure scoring streak end at 230 games.
Lillard's incredible offensive stretch was the third-longest active streak in the NBA behind LeBron James (939) and James Harden (352), according to ESPN Stats & Info.
"It's the fourth team in a row to come out denying me full court. Box-and-one," Lillard told reporters postgame, including ESPN's Kevin Pelton. "I don't remember seeing that many box-and-ones in the NBA, but I mean, they make me play against a crowd.
"Even when I try to get downhill and be aggressive, there's four guys right there. The right play is to kick it ahead, get it out, that was the only option they gave me a lot of times. It's just what it was.''
Toronto used the infamous defensive scheme during last season's NBA Finals against Golden State Warriors guard Stephen Curry. Raptors head coach Nick Nurse - who also serves as the Canadian national team's bench boss - broke it out this past summer at the FIBA World Cup as well.
Lillard is second in the league at 30.5 points per game and will have a chance to start a new streak on Saturday when Portland takes on the San Antonio Spurs.