West Ham United will need to beat another Mancunian club to reach the League Cup quarterfinals.
The Irons will host League Cup holders Manchester City at the London Stadium in the fourth round after beating Manchester United 1-0 in Wednesday's third-round tie at Old Trafford.
Elsewhere, Arsenal were drawn against Leeds United and Liverpool face a short trip to Championship side Preston North End.
Here's Wednesday's fourth-round draw in full:
- Chelsea vs. Southampton
- Arsenal vs. Leeds United
- Stoke City vs. Brentford
- West Ham United vs. Manchester City
- Leicester City vs. Brighton & Hove Albion
- Burnley vs. Tottenham Hotspur
- Queens Park Rangers vs. Sunderland
- Preston North End vs. Liverpool
The last-16 ties will be contested during the week commencing Oct. 25.