Berlin - Flu-hit Bundesliga leaders Borussia Dortmund crashed out of the German Cup on Tuesday, losing a penalty shoot-out at home to Werder Bremen following a 3-3 draw after extra time.
Goalkeeper Jiri Pavlenka was Bremen's hero in the shoot-out as he saved Dortmund's opening attempts from Paco Alcacer and Maximilian Philipp as Bremen won the last-16 tie 4-2 on penalties.
It finished 1-1 over 90 minutes after Dortmund captain Marco Reus rifled home a direct free-kick to cancel out an early goal by Bremen's Milot Rashica.
The game exploded into life with four goals in extra time as Bremen twice equalised, through substitutes Claudio Pizarro and Martin Harnik, to force penalties after Chelsea-bound Christian Pulisic and Achraf Hakimi had scored for Dortmund.
"It's a bitter defeat," admitted Dortmund striker Mario Gotze.
"We shouldn't have conceded two equalisers in extra time and then to lose on penalties is really tough."
Peru veteran Pizarro, who turns 41 in October, was delighted with his 56th German Cup goal.
"That will have done us good - we deserved to go through," beamed the former Chelsea and Bayern Munich striker.
Flu meant Dortmund were without England winger Jadon Sancho and defender Lukasz Piszczek, as well as first-choice goalkeeper Roman Burki and his back-up, Swiss international Marwin Hitz.
It meant third-choice keeper Eric Oelschlagel made his Dortmund debut against Bremen, the club he left last June after six years.
The 23-year-old was beaten after just five minutes when Rashica stabbed home a Max Kruse free-kick to stun the sell-out crowd of 80,500.
Dortmund equalised just before the half-time break when Reus fired home a superb direct free-kick for his 17th goal of the season.
Both sides had chances late in the second half as Oelschlagel made a superb one-handed save from a Kruse free-kick.
Dortmund midfielder Thomas Delaney then hit the crossbar with the 90 minutes up.
Pulisic looked to have settled the matter by netting just before the end of the first period of extra time after dribbling through the away defence.
Bremen came back with Pizarro knocking the ball home at the second attempt in a goal-mouth scramble to make it 2-2 on 108 minutes.
Dortmund regained the lead when defender Achraf Hakimi finished off a move he started on 113 minutes, but Harnik levelled the score in the 119th minute before Pavlenka's heroics in the shoot-out.
Bayern Munich face Hertha Berlin away on Wednesday having lost their last two games at the Olympic Stadium -- crashing 2-0 in the Bundesliga last September and losing May's German Cup final 3-1 to Eintracht Frankfurt.
Germany goalkeeper Manuel Neuer is expected to be back in the Bayern goal wearing a plastic cast after suffering a thumb injury last week.
Earlier on Tuesday Bayer Leverkusen, who pulled off a shock 3-1 win over Bayern last Saturday, were another big name casualty as they slumped to a 2-1 defeat at second-division Heidenheim.
Germany winger Julian Brandt gave Leverkusen the lead, but after Heidenheim striker Nikola Dovedan equalised, midfielder Maurice Multhaup hit the winner 18 minutes from time after previously hitting the bar.
Hamburg were another second-division club to boot a Bundesliga club out of the last 16 when 20-year-old Turkey international Berkay Ozcan scored their second-half winner in a 1-0 victory over Nurnberg.