John Isner has reached his first Grand Slam semifinal on his 41st appearance.
The hard-serving American beat Milos Raonic of Canada 6-7 (5), 7-6 (7), 6-4, 6-3 to set up a meeting with Kevin Anderson of South Africa in Wimbledon's last four.
Isner's 41 attempts to make a semifinal at a major is the second most in the 50-year professional era, behind Sam Querrey, who made the last four at Wimbledon last year with his 42nd try.
Isner has yet to be broken at this year's tournament and saved the only break point he faced on Wednesday. Raonic hit 31 aces to Isner's 25 but was broken three times, including the last game of the match.